 | Leukemia and Lymphoma In Leukemia and Lymphoma: Detection of Minimal Residual Disease, hands-on experts describe and discuss the minimal residual disease (MRD) methods they have successfully pioneered for leukemias and lymphomas. They apply reverse transcription PCR (RT-PCR) to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for Non-Hodgkins Lymphoma and for the monitoring of follicular lymphoma. Additional chapters address the use of real-time quantitative PCR (RQ-PCR), the emergent method of choice, in patients with acute lymphoblastic leukemia (ALL), the evaluation of MRD techniques in clinical trials, and the application of flow cytometry techniques.
Contents:
Flow-Cytometry Methods for the Detection of Residual Leukemia * Flow-Cytometry Based Studies of Minimal Residual Disease in Children with Acute Lymphoblastic Leukemia * PCR Methods for the Detection of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia * Statistical Considerations in the Analysis of Minimal Residual Disease * The Application of Minimal Residual Disease Detection Methodology to the Clinical Decision-Making Process * Measurement of Minimal Residual Disease in Children Undergoing Allogeneic Stem Cell Transplant for Acute Lymphoblastic Leukemia * Molecular Investigation of Minimal Residual Disease in Adult Acute Lymphoblastic Leukemia of B Lineage * Investigation of Minimal Residual Disease in Acute Myeloid Leukemia by Immunophenotyping * Minimal Residual Disease in Acute Myeloid Leukemia: RT-PCR Based Studies of Fusion Transcripts * Minimal Residual Disease in Acute Promyelocytic Leukemia
Francesco Lo Coco and Daniela Diverio * Minimal Residual Disease in Chronic Myelogenous Leukemia: Results of RT-PCR Detection of BCR-ABL Transcripts * Utility of PCR Assessment of Minimal Residual Disease After Stem Cell Transplantation in Non-Hodgkins Lymphoma * Real-Time Polymerase Chain Reaction of Genomic DNA for Quantitation of t(14;18) * Monitoring Follicular Lymphoma by Polymerase Chain Reaction * Editors Notes
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ISBN: 0896039668
Author: Zipf T F Johnston E A
Format: HB
Pages: 257
Publication Date: 01 Nov 2002
Edition : 1 |
