Biopsy Pathology in Colorectal Disease shows how the practising pathologist can extract the maximum of diagnostic value from biopsies of the colon, rectum and anus. With the advances in colonoscopic mucosal biopsy techniques these are amongst the most frequently encountered specimens in hospital histopathology departments. This new edition provides practising pathologists and those in allied disciplines with a thorough guide to the diagnosis of colorectal conditions, both common and rare, and offers expert guidance in the handling of biopsy specimens.

The most valuable information for diagnostic interpretation of the various types of inflammatory disease is presented clearly and succinctly, minimizing the use of non-diagnostic terms such as 'non-specific colitis'. Optimal ways of handling and examining polyps, the assessment of biopsies in motility disorders and the interpretation of biopsies of anal lesions are described. A rational classification and practical approach to dysplasia is presented.

The early chapters describe how to recognize the many different features, both normal and abnormal, which can be regarded as signposts to diagnosis. The significance of these diagnostic signposts is briefly described and cross referenced to later chapters, in which the histological features of the specific diseases are covered in greater depth.


Over 200 colour illustrations


Advice on the best way to handle the specimen and appropriate use of special techniques

A diagnostic approach fully orientated to the needs of current clinical practice

Appropriately referenced text for insight into the wide range of diagnoses
CONTENTS: 1. Introduction
2. Normal features
3. Assessment of abnormalities: diagnostic signposts
4. Infective colitis
5. Ulcerative colitis
6. Crohn's disease
7. Ileoanal pouch pathology
8. Pseudomembranous colitis
9. Microscopic - colitis collagenous colitis, lymphocytic colitis and their variants
10. Ischaemic colitis
11. Iatrogenic disease
12. The differential diagnosis of inflammatory bowel disease
13. Disorders of motility
14. Neoplasia in the colon and rectum and its classification
15. Polyps
16. The diagnosis of malignancy
17. Dysplasia in inflammatory bowel disease
18. Malignant tumours
19. Anal biopsy
20. Miscellaneous conditions