Written and edited by world-renowned authorities, this three-volume work is, to quote a reviewer, 'the definitive textbook about seizures and epilepsy'. This Second Edition is thoroughly updated and gives you a complete print and multimedia package: the three-volume set plus access to an integrated content Website.

More than 300 chapters cover the spectrum of biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Included are detailed discussions of seizure types and epilepsy syndromes; relationships between physiology and clinical events; psychiatric and medical comorbidity; conditions that could be mistaken for epilepsy; and an increasing range of pharmacologic, surgical, and alternative therapies, including vagus nerve stimulation and deep brain stimulation. This edition describes many new antiepileptic drugs, major advances in surgical treatment, and state-of-the-art neuroimaging, EEG, and other technologies for diagnosis and seizure prediction.

A companion Website offers instant access to the complete, fully searchable text, plus an image bank of additional figures, video footage, and annual updates to selected chapters.

CONTENTS: SECTION HEADINGS

EPIDEMIOLOGY, PATHOLOGY, AND GENETICS OF EPILEPSY
Epidemiology
Neuropathology
Genetics

THE NEUROBIOLOGY OF EPILEPSY
Mechanisms of Normal Neuronal Excitability
Mechanisms of Epileptogenesis and Epileptogenicity

PHENOMENOLOGY
Epileptic Seizures
Status Epilepticus
Epileptic Disorders

DIAGNOSTIC EVALUATION
Routine Investigations
EEG
Neuroimaging
New Directions
Neuropsychological Evaluation
Long-Term Monitoring

GENERAL TREATMENT CONSIDERATIONS
General Considerations
Principles of Drug Treatment
Strategies for Pharmacotherapy
Special Therapeutic Considerations
Alternative Approaches

ANTIEPILEPTIC DRUGS
Antiepileptic Drug Development
Antiepileptic Drugs

SURGICAL THERAPY
Candidate Selection
Invasive Monitoring Techniques
Functional Mapping Techniques
Therapeutic Surgical Procedures
Postoperative Follow-Up

CLINICAL BIOLOGY OF EPILEPSY
Biorhythms and the Autonomic Nervous System
Comorbidity
Neuroendocrinology

PSYCHIATRIC AND SOCIAL ISSUES
Psychiatric Issues
Social Issues

EPILEPSY SYNDROMES
Neonatal Syndromes
Syndromes of Infancy and Early Childhood
Syndromes of Later Childhood and Adolescence
Non Age-Related and Special Syndromes
Diseases Associated with Epilepsy

DISORDERS THAT CAN BE CONFUSED WITH EPILEPSY
Systemic Disturbances
Neurological Disturbances
Psychiatric Disturbances

DELIVERY OF HEALTH CARE AND SOCIOECONOMIC ISSUES
Organization of Health Care in Different Countries
Specialized Centers for Epilepsy
Cost and Allocation of Resources